Anime Last Stand Tier List (December 2025) Best Units Ranked
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The Mutation Machine in Plants vs Brainrots has revolutionized how players boost their income and damage output. Introduced in the Merge Madness update, this powerful mechanic allows you to combine two mutated plants or brainrots of the same type to create hybrid variants with significantly enhanced multipliers. In this comprehensive guide, I’ll walk you through everything you need to know about using the Mutation Machine effectively, including all rewards, optimal strategies, and expert tips to maximize your gains.
| Quick Facts | Details |
|---|---|
| Location | Central Island (Rebirth 1 required) |
| EXP Required | 300 EXP per merge |
| Merge Time | 6-7 minutes (3-3.5 minutes during Mutation Mania) |
| Total Rewards | 25+ exclusive items |
| Best Time to Merge | During Mutation Mania weather (2x speed) |
The Mutation Machine represents one of the most significant progression systems in Plants vs Brainrots. By merging two identical plants or brainrots with different mutations, you create a single unit that inherits both mutation effects and increased stat multipliers. This mechanic is essential for players looking to scale their cash generation and defensive capabilities efficiently.
Unlike the standard Fuse Machine that combines different plant and brainrot types, the Mutation Machine specifically targets mutation combinations. When you successfully merge mutations, the resulting unit gains a combined multiplier that can dramatically increase its value. For example, merging a Frozen mutation (3x multiplier) with a Neon mutation (5x multiplier) creates a FrozenNeon variant with a 15x income multiplier for brainrots.
The machine also contributes directly to the Merge Madness Event progression, with each successful merge unlocking exclusive rewards including premium brainrots, rare plant seeds, valuable gear, and substantial cash bonuses.
Accessing and operating the Mutation Machine requires specific prerequisites and a clear understanding of the merging process. Here’s my complete step by step walkthrough based on extensive testing:
Before you can use the Mutation Machine, you must meet these requirements:
Step 1: Travel to Central Island
Use the mirror at your base to teleport directly to Central Island. The Mutation Machine is positioned prominently next to the Plant Extractor and EXP Machine, making it easy to locate once you arrive.
Step 2: Insert Your Mutated Units
Hold your first mutated plant or brainrot and press the E key while facing the “Mutation 1” slot. The machine will accept the unit if it has a valid mutation. Repeat this process for the “Mutation 2” slot with another unit of the same base type but with a different mutation.
Important notes:
Step 3: Power the Machine with EXP
Walk to the EXP station on the left side of the Mutation Machine. Hold out any EXP item from your inventory and use it to fill the EXP bar. You need exactly 300 EXP total, which translates to:
Pro tip: Any overflow EXP carries over to your next merge, so don’t worry about wasting resources if you add more than 300 EXP.
Step 4: Initiate the Merge
Once both slots are filled and the EXP bar reaches 300, head to the right side of the machine and pull the Mix lever. The merging process will begin immediately, displaying a timer based on the rarity of your units.
Step 5: Claim Your Merged Unit
Standard merges take between 6-7 minutes depending on rarity. During Mutation Mania weather events, this time is cut in half to approximately 3-3.5 minutes. You can skip the timer by spending Robux, but I recommend waiting unless you’re in a rush for event rewards.
Once complete, the merged unit automatically transfers to your inventory with its new hybrid mutation and enhanced stats.
The Merge Madness Event offers 25 exclusive rewards for completing mutation merges. Each reward milestone provides valuable items that accelerate your progression. Here’s the complete breakdown based on verified community data:
| Merge Count | Rewards | Type |
|---|---|---|
| 1 | 8.7B Cash | Currency |
| 2 | 3 Premium Water Bucket + 8.7B Cash | Resources |
| 3 | 1 Orcalelo Orcala + 3 Frost Grenade | Brainrot/Items |
| 4 | 8.7B Cash | Currency |
| 5 | 1 Sunflower Seed + 3 Premium Water Bucket + 2 Base Card Packs | Mixed |
| 6 | Witch Potion | Item |
| 7 | Gangster Footera + Cash | Brainrot |
| 8 | Sunflower Seed + Cash | Seed |
| 9 | Dragon Fruit Seed + Bandito Bobrito + Cash | Mixed |
| 10 | 8.7B Cash | Currency |
| 11 | Frost Grenade + Orcalelo Orcala | Items/Brainrot |
| 12-21 | Various Items (Being Updated) | Mixed |
| 22 | Dr. Flalarino + Blohazellno Seed | Brainrot/Seed |
| 23-25 | Various Items (Being Updated) | Mixed |
From my experience grinding through these rewards, several stand out as particularly valuable:
Premium Water Buckets: These accelerate plant growth significantly, making them essential for maintaining a strong defense while focusing on mutations.
Rare Brainrot Seeds: Units like Orcalelo Orcala, Gangster Footera, and Bandito Bobrito offer excellent base stats that become exponentially better when mutated.
Dr. Flalarino: This milestone 22 reward is one of the most powerful brainrots in the game, with exceptional income generation even before mutations.
Card Packs: Base Card Packs provide random rewards that can include exclusive items not available through normal gameplay.
EXP items are the fuel for the Mutation Machine, and efficient farming strategies make a massive difference in how quickly you can complete merges. I’ve tested multiple methods, and here are the most effective approaches:
Brainrot Invasions spawn automatically every 10 minutes across all servers. During these events, defeat as many brainrots as possible to earn EXP items as drops. The higher tier invasions reward better EXP items including Flasks, Vials, and Stars.
Strategy tips:
The Plant Extractor, located next to the Mutation Machine on Central Island, converts unwanted plants into EXP items. This method provides consistent, controllable EXP generation.
Best plants to extract:
Conversion rates vary by plant tier, with higher tier plants yielding more EXP. However, I recommend extracting only low tier plants to preserve your defensive capabilities.
Special events often reward EXP items as completion bonuses. Admin Events, weather changes, and limited time challenges frequently include EXP Bottles, Vials, or Flasks. Stay active during these events to stockpile resources for future merges.
The true power of the Mutation Machine lies in understanding which mutation combinations create the most valuable results. Not all combinations are created equal, and strategic merging can dramatically impact your income generation.
Here are the base multipliers for common mutations:
The Merge Madness update introduced four new mutation types with 2x multipliers:
When you merge two mutations, the resulting multiplier combines both effects. However, the bonuses are not simply multiplicative. Based on extensive community testing, merged mutations typically provide:
For maximizing brainrot income generation, prioritize these combinations:
For plants focused on damage output and defense:
The Mutation Mania weather event is your best friend for efficient merging. This event occurs every hour and lasts for 10 minutes, reducing merge time by 50%. Here’s how to maximize this window:
Before Mutation Mania activates:
When Mutation Mania begins:
With perfect execution, you can complete 3 merges during a single Mutation Mania event, compared to just 1 merge under normal conditions.
Mutation Mania follows a predictable schedule:
Set an alarm or timer to ensure you don’t miss these crucial windows, especially if you’re grinding for specific reward milestones.
After completing over 50 merges myself, I’ve developed several advanced strategies that optimize the process:
Since merged units only gain 1-2x the stats of consumed units, use your weakest mutated plants and brainrots for merging. Save your strongest mutated units for actual gameplay where their full power is needed.
For example, if you have a low tier mutated Cacti and a high tier mutated Tomatrio, merge the Cacti first. The resulting unit will still be useful, but you haven’t sacrificed your best defender.
Not all rewards are equally valuable. If you’re specifically targeting Dr. Flalarino (reward 22), calculate exactly how many merges you need and prepare accordingly. This prevents wasting resources on early merges if you’re only interested in high tier rewards.
Combine Mutation Mania with other beneficial events for maximum efficiency:
If you’re struggling to get specific mutations naturally, consider trading with other players. The Plants vs Brainrots community is active in trading mutated units, and you can often acquire exactly what you need for specific combinations through the official Discord server.
Keep track of which mutation combinations you’ve tried and their results. This helps identify which combinations provide the best stat boosts and prevents wasting time on suboptimal merges.
Through my extensive experience and watching countless players, I’ve identified critical mistakes that waste time and resources:
Never merge your strongest mutated plants and brainrots. You need these for defending against waves and generating income during normal gameplay. Always merge duplicates or weaker variants.
Merging during normal time wastes precious minutes. A single 7-minute merge during standard gameplay could be 3-4 merges during Mutation Mania events. The time efficiency difference is massive.
The machine only accepts units with different mutations. Trying to merge two Gold mutated units will fail. Always verify your units have distinct mutations before initiating.
Running out of EXP mid event wastes the Mutation Mania window. Always maintain a reserve of at least 900 EXP before events start.
Every merge counts toward your Merge Madness Event progress, but only completed merges register. Canceling or abandoning merges means you lose both the units and the event progress.
No, you cannot merge a plant with a brainrot in the Mutation Machine. Both units must be either plants or brainrots, and they must be the same base type. For example, you can merge two mutated 67s together, but you cannot merge a 67 with a Tomatrio or a plant with a brainrot.
No, mutations do not transfer to the standard Fuse Machine. If you fuse a mutated plant or brainrot using the regular Fuse Machine, the resulting Fused Brainrot will be the base version without mutations. This is why the Mutation Machine is separate it specifically preserves and combines mutations.
Mutations spawn randomly through several methods:
Increase your chances by playing during beneficial weather conditions and participating in every event.
Yes, by merging during Mutation Mania weather events. This natural in game mechanic reduces merge time by 50% without spending any Robux. There’s no other way to speed up the process besides waiting for these events or paying to skip.
Any EXP beyond the 300 required automatically carries over to your next merge. For example, if you add 500 EXP for one merge, the extra 200 EXP will already be applied when you start your next merge. This prevents resource waste.
No, there are no restrictions on which mutations you can combine, as long as they’re on the same type of plant or brainrot and the mutations are different. You can merge any Standard mutation with any Admin mutation, any weather exclusive mutation with any natural mutation, and so on.
The Mutation Machine in Plants vs Brainrots is a game changing feature that allows dedicated players to create incredibly powerful hybrid units. By understanding the merging process, optimizing your EXP farming, timing your merges during Mutation Mania events, and avoiding common mistakes, you can rapidly progress through the Merge Madness Event rewards while building an unstoppable collection of super mutated plants and brainrots.
Remember to save and bookmark this guide for quick reference, especially when planning your merging strategies around event timings. The Mutation Machine rewards are substantial, and with consistent effort, you’ll unlock every exclusive item while maintaining a powerful defensive roster.
For more Plants vs Brainrots content, check out our complete All Brainrots in Plants vs Brainrots Guide and Plants Vs Brainrots Admin Chest Guide for additional progression tips and strategies.
